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Stereoslective addition reaction to ketimines
Franc, Michael
This diploma thesis deals with the stereoselective addition reaction of benzothiophenone derivatives to ketimines derived from isatin using bifunctional organocatalysis. The stereoselective addition reaction was optimized to provide the appropriate reaction conditions which were subsequently used to study the scope of the reaction. Keywords Organocatalysis, stereoselective synthesis, bifunctional organocatalysts, ketimines, sulphur heterocykles.
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The use of alkylideneheterocycles for the synthesis of spirocyclic compounds
Vopálenská, Andrea ; Veselý, Jan (advisor) ; Matoušová, Eliška (referee)
This bachelor thesis is focused on the stereoselective Michael-alkylation reaction of alkylidene heterocycles using bifunctional organocatalysis. Within the thesis, suitable starting materials were first prepared and then the organocatalytic reaction leading to the formation of spirocyclic compounds was optimized. Under optimized conditions, a study of the scope of application of the method on selected derivatives was also performed and the optical purity of the products was determined. Key words Organocatalysis, asymmetric synthesis, cascade reaction, Michael reaction, bifunctional organocatalysts, spirocyclic compounds
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Stereoslective addition reaction to ketimines
Franc, Michael ; Veselý, Jan (advisor) ; Kotora, Martin (referee)
This diploma thesis deals with the stereoselective addition reaction of benzothiophenone derivatives to ketimines derived from isatin using bifunctional organocatalysis. The stereoselective addition reaction was optimized to provide the appropriate reaction conditions which were subsequently used to study the scope of the reaction. Keywords Organocatalysis, stereoselective synthesis, bifunctional organocatalysts, ketimines, sulphur heterocykles.
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